Mark’s Drugstore in Guthrie, Oklahoma opened in 1953 and is one of the oldest operating drug stores left in the Sooner State. This small town drugstore is still family owned and operated and is a local hangout where everybody knows everybody. You can get your morning coffee, pick up your medicine, grab a gift and so much more. Take a trip to Guthrie and visit this drugstore that’s one of the last of its kind. As they say in Guthrie, “You have not seen Guthrie if you don’t visit Mark’s Drug!”

Mark’s Drugs is located in the heart of downtown Guthrie at 112 West Oklahoma Avenue, Guthrie, OK.

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This drugstore isn’t your typical, chain drugstore. They have a soda fountain that serves root beer floats, Italian creme soda, coffee, espresso, ice cream and more goodies.

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They want you to come in and relax, surf the web on the free wi-fi, watch the game, use the restroom, drink your coffee or just make yourself at home.

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This local drugstore also has a gift shop with many unique items.

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You can also pick-up some Oklahoma t-shirts and show off your Sooner pride.

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From hats to flashlights to candles, it’s your one-stop shop for everything.

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And don’t forget to buy some of their delicious jelly that is handmade in Noble, Oklahoma. Flavors include: basil apple, cinnamon apple, sand plum and rum pear.

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You may even score some free samples while visiting the friendliest pharmacy in town.

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This award-winning drugstore has been recognized for its friendly service, best pharmacist, best atmosphere and best coffee. They also offer 24-hour service and free local delivery.

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Check out our previous article about Guthrie, Oklahoma. While visiting Mark’s Drug, you can check out all of Guthrie’s other great places too.

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